Allergen, Not An AllergenFeaturedSkin

THIURAM: Allergen or Not An Allergen?

Allergen.

Thiuram:

What do onions, erasers, condoms, garden hoses, makeup sponges, balloons, sneakers and swimsuits have in common? Many contain thiuram or thiuram mix, or residue from thiuram sprayed on them.

What is frustrating about allergens like thiuram is that they can be in so many things that, besides containing thiuram, don’t seem to have anything to do with each other. Consequently, it can be hard to avoid them.

Thiuram is in rubber, which might be easy to spot in gloves and tennis shoes…but may be less obvious in rubberized phone cases and travel mug holders, or in the stencils used to apply henna tattoos. There can also be rubber in stretchy travel pillows and in the glues used in bandages, as well as in mattresses, cables, and leather shoes.

Furthermore, thiuram is an allowed germicide, so it’s not uncommon to find it on fresh vegetables and fruits, on lawns, flowers and golf courses, on fabrics and wood, and even in some sunscreens and soaps.

If you have a history of sensitive skin, don’t guess: random trial and error can cause more damage. Ask your dermatologist about a patch test. If your patch test results show a sensitivity to thiuram mix:

  • Pay close attention to your doctor’s instructions;
  • Opt for organic produce (to get certified as organic means not using any germicides on the plants);
  • Look for rubber- or latex-free clothing, including underwear and socks (companies like Cottonique specialize in this);
  • Use skincare, makeup and makeup applicators without rubber or rubber-related ingredients (VMV Hypoallergenics can customize recommendations based on your patch test results and avoids rubber-related ingredients in everything, including packaging).

References: 

Regularly published reports on the most common allergens by the North American Contact Dermatitis Group and European Surveillance System on Contact Allergies (based on over 28,000 patch test results, combined), plus other studies. Remember, we are all individuals — just because an ingredient is not on the most common allergen lists does not mean you cannot be sensitive to it, or that it will not become an allergen. These references, being based on so many patch test results, are a good basis but it is always best to get a patch test yourself.

1. Warshaw, E.M., Maibach, H.I., Taylor, J.S., et al. North American contact dermatitis group patch test results: 2011-2012. Dermatitis. 2015; 26: 49-59
2. W Uter et al. The European Baseline Series in 10 European Countries, 2005/2006–Results of the European Surveillance System on Contact Allergies (ESSCA). Contact Dermatitis 61 (1), 31-38.7 2009
3. Wetter, DA et al. Results of patch testing to personal care product allergens in a standard series and a supplemental cosmetic series: An analysis of 945 patients from the Mayo Clinic Contact Dermatitis Group, 2000-2007. J Am Acad Dermatol. 2010 Nov;63(5):789-98.
4. Verallo-Rowell VM. The validated hypoallergenic cosmetics rating system: its 30-year evolution and effect on the prevalence of cosmetic reactions. Dermatitis 2011 Apr; 22(2):80-97
5. Ruby Pawankar et al. World Health Organization. White Book on Allergy 2011-2012 Executive Summary.
6. Misery L et al. Sensitive skin in the American population: prevalence, clinical data, and role of the dermatologist. Int J Dermatol. 2011 Aug;50(8):961-7.
7. Warshaw EM1, Maibach HI, Taylor JS, Sasseville D, DeKoven JG, Zirwas MJ, Fransway AF, Mathias CG, Zug KA, DeLeo VA, Fowler JF Jr, Marks JG, Pratt MD, Storrs FJ, Belsito DV. North American contact dermatitis group patch test results: 2011-2012.Dermatitis. 2015 Jan-Feb;26(1):49-59.
8. Warshaw, E et al. Allergic patch test reactions associated with cosmetics: Retrospective analysis of cross-sectional data from the North American Contact Dermatitis Group, 2001-2004. J AmAcadDermatol 2009;60:23-38. 
9. Foliaki S et al. Antibiotic use in infancy and symptoms of asthma, rhinoconjunctivitis, and eczema in children 6 and 7 years old: International Study of Asthma and Allergies in Childhood Phase III. J Allergy Clin Immunol. 2009 Nov;124(5):982-9.
10. Kei EF et al. Role of the gut microbiota in defining human health. Expert Rev Anti Infect Ther. 2010 Apr; 8(4): 435–454.
11. Thavagnanam S et al. A meta-analysis of the association between Caesarean section and childhood asthma. Clin Exp Allergy. 2008;38(4):629–633.

12. Marks JG, Belsito DV, DeLeo VA, et al. North American Contact Dermatitis Group patch-test results, 1998 to 2000. Am J Contact Dermat. 2003;14(2):59-62.
13. Warshaw EM, Belsito DV, Taylor JS, et al. North American Contact Dermatitis Group patch test results: 2009 to 2010. Dermatitis. 2013;24(2):50-99.

For more:

On the prevalence of skin allergies, see Skin Allergies Are More Common Than Ever and One In Four Is Allergic to Common Skin Care And Cosmetic Ingredients.

To learn more about the VH-Rating System and hypoallergenicity, click here.

3 Comments

  1. […] be latex contamination from where the nitrile gloves are manufactured, or rubber accelerators like thiuram. Note that airborne contact dermatitis has also been reported, so if you have patch tested positive […]

  2. […] of the top contact allergens to watch out for in most earphones and headphones include: rubber, thiuram, nickel, benzophenones, and dyes. Silicones tend to be fine but some silicone ear tips might […]

  3. […] rubber (and thiuram) are top skin allergens and they regularly cause contact dermatitis in gloves as well as other […]

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